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ISRIB Powder: molecular data, studies & sources

ISRIB Powder is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C22H24Cl2N2O4
Molecular weight (MW)
451.3 g/mol
PubChem compound ID
1011240
Record title
2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 1011240 · retrieved 2026-09-21

2D molecular structure for ISRIB Powder, PubChem CID 1011240
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
InChIKey
HJGMCDHQPXTGAV-UHFFFAOYSA-N
SMILES
C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
Machine-readable PubChem source
Calculated molecular descriptors
Monoisotopic (exact) mass450.1113 Da
Heavy atoms30
Hydrogen-bond donors2
Hydrogen-bond acceptors4
Rotatable bonds8
Topological polar surface area76.7 Ų
Calculated logP (Crippen)3.99
Rings3
Stereocenters2
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list ISRIB as an intervention. Studies that only measure the molecule as a biomarker are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

No matching human study was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

    Preclinical research, reviews & other publications

    Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

    1. Review · secondary evidence

      ALSUntangled #80: ISRIB (Integrated stress response InhiBitor).

      Mascias Cadavid J, Mena Bravo A, Barkhaus P et al. · Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025

      PMID 40762148 · DOI: 10.1080/21678421.2025.2542919

    2. Research publication · design requires review

      ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

      Zyryanova AF, Kashiwagi K, Rato C et al. · Molecular cell · 2021

      PMID 33220178 · DOI: 10.1016/j.molcel.2020.10.031

    3. Review · secondary evidence

      Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.

      Anand AA, Walter P · The FEBS journal · 2020

      PMID 31550413 · DOI: 10.1111/febs.15073

    ISRIB Powder supplier sources

    Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

    ISRIB Powder for sale: compare prices, sizes and forms from every tracked supplier →

    SupplierRecorded packagesExample source listing
    Amino USAUSD500mg Powder1 recorded offers500mg Powder · $55.00Checked Oct 7, 2026Supplier listing

    Reference sources & further reading

    The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

    Search for additional research

    These links run searches; their results have not been individually reviewed and can include unrelated compounds.

    Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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