Nootropics

ISRIB Powder: molecular data, studies & sources

ISRIB Powder is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked 2026-09-21 · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF): C22H24Cl2N2O4
Molecular weight (MW): 451.3 g/mol
PubChem compound ID: 1011240
Record title: 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 1011240 · retrieved 2026-09-21

PubChem 2D molecular structure for ISRIB Powder, CID 1011240 — 2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.

Chemical identifiers and source data

IUPAC name: 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
InChIKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N
SMILES: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl

Machine-readable PubChem source

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

No matching human study was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

Review · secondary evidence
ALSUntangled #80: ISRIB (Integrated stress response InhiBitor).
Mascias Cadavid J, Mena Bravo A, Barkhaus P et al. · Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025
PMID 40762148 · DOI: 10.1080/21678421.2025.2542919
Research publication · design requires review
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Zyryanova AF, Kashiwagi K, Rato C et al. · Molecular cell · 2021
PMID 33220178 · DOI: 10.1016/j.molcel.2020.10.031
Review · secondary evidence
Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.
Anand AA, Walter P · The FEBS journal · 2020
PMID 31550413 · DOI: 10.1111/febs.15073

ISRIB Powder supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Compare all ISRIB Powder sizes, forms and supplier prices →

Supplier	Recorded packages	Example source listing
Amino USAUSD	500mg Powder1 recorded offers	500mg Powder · $49.50Checked Sep 16, 2026Supplier listing

Reference sources & further reading

PubChem compound record 1011240 — chemical identity and structure.
Wikipedia: ISRIB — Background encyclopedia; not a primary clinical source.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.