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Nootropics · Peptides

Semax: molecular data, studies & sources

Semax is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C37H51N9O10S
Molecular weight (MW)
813.9 g/mol
PubChem compound ID
9811102
Record title
ACTH (4-7), Pro-Gly-Pro-

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 9811102 · retrieved 2026-09-21

2D molecular structure for Semax, PubChem CID 9811102
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
InChIKey
AFEHBIGDWIGTEH-AQRCPPRCSA-N
SMILES
CSCC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(=O)O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
9811102
CAS Registry Number
80714-61-0via ChemIDplus, FDA GSRS
FDA UNII
I5FAL2585H
InChIKey
AFEHBIGDWIGTEH-AQRCPPRCSA-N

Peptide sequence · 7 residues (one-letter code; X marks a residue without a one-letter code)

MEHFPGP

Condensed notation with terminal groups and non-standard residues

H-Met-Glu-His-Phe-Pro-Gly-Pro-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass813.3480 Da
Heavy atoms57
Hydrogen-bond donors8
Hydrogen-bond acceptors11
Rotatable bonds21
Topological polar surface area286.3 Ų
Calculated logP (Crippen)-1.22
Rings4
Stereocenters6
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Semax as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Semax, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    [The efficacy of semax in the tretament of patients at different stages of ischemic stroke].

    Gusev EI, Martynov MY, Kostenko EV et al. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2018

    PMID 29798983 · DOI: 10.17116/jnevro20181183261-68

  2. Human study · PubMed trial index Compound given to participants

    [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)].

    Gusev EI, Skvortsova VI, Miasoedov NF et al. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 1997

    PMID 11517472

  3. Human study · PubMed trial index Compound given to participants

    [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease].

    Polunin GS, Nurieva SM, Baiandin DL et al. · Vestnik oftalmologii · 2000

    PMID 10741256

  4. Human study · PubMed trial index Compound given to participants

    [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

    Serdiuk AV, Levitskiĭ GN, Miasoedov NF et al. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2007

    PMID 18379501

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Research publication · design requires review

    Functional Connectomic Approach to Studying Selank and Semax Effects.

    Panikratova YR, Lebedeva IS, Sokolov OY et al. · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020

    PMID 32342318 · DOI: 10.1134/S001249662001007X

Semax supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Semax for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $50.00Stale observation · Checked Sep 30, 2026Supplier listing, Semax 10mg Vial, Blank Peptides, opens in a new tab
American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $65.00Checked Nov 6, 2026Supplier listing, Semax 10mg Vial, American Peptides, opens in a new tab
Amino ClubUSD10mg Vial · 25mg Spray2 recorded offers10mg Vial · $29.95Stale observation · Checked Oct 14, 2026Supplier listing, Semax 10mg Vial, Amino Club, opens in a new tab
Nova Peptide SupplyUSD10mg Vial1 recorded offers10mg Vial · $34.99Checked Nov 6, 2026Supplier listing, Semax 10mg Vial, Nova Peptide Supply, opens in a new tab
Amino USAUSD30mg Vial1 recorded offers30mg Vial · $75.00Checked Nov 6, 2026Supplier listing, Semax 30mg Vial, Amino USA, opens in a new tab
Cenexa LabsUSD10mg Vial · 5mg Vial · 10mg Spray3 recorded offers10mg Vial · $43.99Checked Nov 6, 2026Supplier listing, Semax 10mg Vial, Cenexa Labs, opens in a new tab
LA PeptidesUSD10mg Spray · 10mg Vial2 recorded offers10mg Spray · $59.99Checked Nov 3, 2026Supplier listing, Semax 10mg Spray, LA Peptides, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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