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Bioregulators · Peptides

Epithalon: molecular data, studies & sources

Epithalon is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C14H22N4O9
Molecular weight (MW)
390.35 g/mol
PubChem compound ID
219042
Record title
Epitalon

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 219042 · retrieved 2026-09-21

2D molecular structure for Epithalon, PubChem CID 219042
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
InChIKey
HGHOBRRUMWJWCU-FXQIFTODSA-N
SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
219042
CAS Registry Number
307297-39-8via ChemIDplus, EPA DSSTox, FDA GSRS
FDA UNII
O65P17785G
InChIKey
HGHOBRRUMWJWCU-FXQIFTODSA-N
Wikidata
Q27285389

Peptide sequence · 4 residues (one-letter code; X marks a residue without a one-letter code)

AEDG

Condensed notation with terminal groups and non-standard residues

H-Ala-Glu-Asp-Gly-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass390.1387 Da
Heavy atoms27
Hydrogen-bond donors7
Hydrogen-bond acceptors7
Rotatable bonds12
Topological polar surface area225.2 Ų
Calculated logP (Crippen)-3.16
Rings0
Stereocenters3
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Epitalon as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Epitalon, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.

    Khavinson V, Razumovsky M, Trofimova S et al. · Neuro endocrinology letters · 2002

    PMID 12195242

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Review · secondary evidence

    Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.

    Araj SK, Brzezik J, Mądra-Gackowska K et al. · International journal of molecular sciences · 2025

    PMID 40141333 · DOI: 10.3390/ijms26062691

  2. Research publication · design requires review

    Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

    Al-Dulaimi S, Thomas R, Matta S et al. · Biogerontology · 2025

    PMID 40908429 · DOI: 10.1007/s10522-025-10315-x

  3. Review · secondary evidence

    Peptides and Ageing.

    Khavinson VKh · Neuro endocrinology letters · 2002

    PMID 12374906

Epithalon supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Epithalon for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $40.00Stale observation · Checked Sep 30, 2026Supplier listing, Epithalon 10mg Vial, Blank Peptides, opens in a new tab
American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $60.00Checked Oct 13, 2026Supplier listing, Epithalon 10mg Vial, American Peptides, opens in a new tab
Amino ClubUSD10mg Vial1 recorded offers10mg Vial · $29.99Stale observation · Checked Sep 28, 2026Supplier listing, Epithalon 10mg Vial, Amino Club, opens in a new tab
Amino USAUSD10mg Vial · 50mg Vial2 recorded offers10mg Vial · $30.00Checked Oct 13, 2026Supplier listing, Epithalon 10mg Vial, Amino USA, opens in a new tab
Cenexa LabsUSD10mg Vial1 recorded offers10mg Vial · $54.99Checked Oct 13, 2026Supplier listing, Epithalon 10mg Vial, Cenexa Labs, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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