Phenibut HCl Powder: molecular data, studies & sources

Molecular formula, weight & structure

Molecular formula (MF)

C10H14ClNO2

Molecular weight (MW)

215.67 g/mol

PubChem compound ID

11499499

Record title

4-Amino-3-phenylbutyric acid hydrochloride

This record includes hydrochloride. Its molecular weight must not be replaced with the free amino acid value. Clinical publications concern the preparations used in those studies, not certification of a listed supplier powder.

Source: PubChem CID 11499499 · retrieved 2026-09-21 · Identity cross-reference

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Phenibut hydrochloride as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Phenibut hydrochloride, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

1. Human observational study Compound given to participants

   Efficacy of Noofen 250 mg Capsules for the Management of Anxious-Neurotic Symptoms in Patients with Adjustment Disorder.

   Tērauds E, Dansone G, Troshina Y et al. · Journal of clinical medicine · 2025

   Non-interventional observational study of a named capsule preparation in 90 patients. No randomized placebo group; not evidence of equivalence to FAA or HCl supplier powders.

   PMID 40807194 · DOI: 10.3390/jcm14155570

2. Human study · PubMed trial index Compound given to participants

   [Bioequivalence of anvifen and phenibut].

   Zhezlova AV, Belolipetskaia VG, Blagodatskikh SV et al. · Eksperimental'naia i klinicheskaia farmakologiia · 2011

   PMID 21809698

3. Human study · PubMed trial index Compound given to participants

   [Effect of phenibut, obsidan and their combination on the human functional state in hyperthermia].

   Makarov VI, Tiurenkov IN, Klauchek SV et al. · Fiziologiia cheloveka · 1998

   PMID 9567480

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

1. Review · secondary evidence

   Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.

   Kupats E, Vrublevska J, Zvejniece B et al. · Pharmacopsychiatry · 2020

   Systematic review of clinical-trial safety reports and dependence/intoxication case reports. A review is secondary evidence and includes heterogeneous exposures.

   PMID 32340063 · DOI: 10.1055/a-1151-5017

2. Review · secondary evidence

   Phenibut: A drug with one too many "buts".

   Gurley BJ, Koturbash I · Basic & clinical pharmacology & toxicology · 2024

   PMID 39197876 · DOI: 10.1111/bcpt.14075

Phenibut HCl Powder supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Phenibut HCl Powder for sale: compare prices, sizes and forms from every tracked supplier →

Reference sources & further reading

• PubChem compound record 11499499 — chemical identity and structure.
• Grokipedia: Phenibut — Background encyclopedia; not a primary clinical source.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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