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Triptorelin: molecular data, studies & sources

Triptorelin is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C64H82N18O13
Molecular weight (MW)
1311.4 g/mol
PubChem compound ID
25074470
Record title
Triptorelin

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 25074470 · retrieved 2026-09-21

2D molecular structure for Triptorelin, PubChem CID 25074470
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKey
VXKHXGOKWPXYNA-PGBVPBMZSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
Machine-readable PubChem source
Calculated molecular descriptors
Monoisotopic (exact) mass1310.6309 Da
Heavy atoms95
Hydrogen-bond donors17
Hydrogen-bond acceptors15
Rotatable bonds33
Topological polar surface area490.4 Ų
Calculated logP (Crippen)-2.29
Rings8
Stereocenters9
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Triptorelin as an intervention. Studies that only measure the molecule as a biomarker are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

40 registered studies matched, 18 currently active or recruiting.

StudyPhase · statusConditionsSponsor · size
Intranasal Nafarelin Compared to Subcutaneous Triptorelin for Triggering Final Oocyte Maturation in Ovarian Stimulation: a Non-inferiority Randomised Controlled Clinical TrialNCT06763926 · start 2026-10-15 · primary completion 2028-01-15Phase 4Not Yet RecruitingFertility PreservationFundacion Dexeus154 participants
Assessing the Efficacy of Neoadjuvant Androgen Deprivation Therapy (ADT) Utilizing 18F-Flotufolastat PSMA PET/CT in Patients With High-Risk Localized Prostate Cancer (LHRPC)NCT07455903 · start 2026-07-29 · primary completion 2030-02Phase 2RecruitingProstate Cancer · Localized Prostate CarcinomaBaptist Health South Florida50 participants
A Randomized Controlled Study of Ultra-Long GnRH-a Pretreatment to Improve Frozen-Thawed Embryo Transfer Outcomes in Patients With Deep Infiltrating EndometriosisNCT07696351 · start 2025-08-01 · primary completion 2026-12-31Phase 4RecruitingDeep Infiltrating Endometriosis (DIE) · InfertilityLi-jun Ding120 participants
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults With CancerNCT06513962 · start 2025-02-27 · primary completion 2029-10-30Phase 3RecruitingHematopoietic and Lymphatic System Neoplasm · Malignant Solid NeoplasmChildren's Oncology Group60 participants
Ovulation Trigger Strategies in Women With Low Ovarian Reserve Undergoing Fresh In Vitro Fertilization Cycles: A Prospective Randomized Controlled Trial (TRIGGERBEST)NCT07816562 · start 2024-09-17 · primary completion 2027-07-01Phase 3RecruitingLow Ovarian Reserve · Poor Ovarian ResponseFundación para la Investigación del Hospital Clínico de Valencia126 participants
A Randomized Phase II Study of Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients: ESCALATE StudyNCT06225284 · start 2024-08-22 · primary completion 2026-12Phase 2RecruitingTriple Negative Breast Cancer · Premenopausal Breast CancerNational Taiwan University Hospital124 participants
The Effects of the 3-month Formulation of Triptorelin (TP) Compared to the 1-month Formulation on the Efficacy, Glucose and Lipid Metabolism, and Bone Mineral Density(BMD) in Idiopathic Central Precocious Puberty(ICPP)NCT06487143 · start 2024-07-01 · primary completion 2026-12-30Phase 4Not Yet RecruitingCentral Precocious PubertySun Yat-Sen Memorial Hospital of Sun Yat-Sen University134 participants
Luteal Phase Support With GnRH Agonist Alone After GnRH Agonist Triggering and Fresh Embryo Transfer Compared to the Reference Protocol (hCG Triggering and Progesterone Luteal Support): a Randomised Controlled TrialNCT06150703 · start 2024-06-27 · primary completion 2027-09Phase 3RecruitingIn Vitro Fertilization · ICSI Intracytoplasmic Spermatozoid InjectionAssistance Publique - Hôpitaux de Paris652 participants
Effect of GnRH Agonist Administration on Decreasing VAS, Estradiol, and Anti Mullerian Hormone in Endometriosis Cyst PatientsNCT06525155 · start 2024-01-02 · primary completion 2025-02Phase 3RecruitingEndometriosisRumah Sakit Pusat Angkatan Darat Gatot Soebroto32 participants
A Phase II Study of the Use of MRI-defined Focal Boosts With Stereotactic Body Radiotherapy for Localized Prostate CancerNCT05851547 · start 2023-11-23 · primary completion 2027-06Phase 2RecruitingProstatic NeoplasmsOttawa Hospital Research Institute54 participants
Show 30 more registered studies
StudyPhase · statusConditionsSponsor · size
A Phase 3 Randomised Double-Blinded Placebo-Controlled Study of Use of GnRHa During Chemotherapy for Fertility Protection of Young Women and Teenagers With CancerNCT05328258 · start 2023-03-31 · primary completion 2028-01-01Phase 3RecruitingBreast Cancer Female · Acute Leukemia · Lymphoma · Osteosarcoma · Soft Tissue Sarcoma · Ewing SarcomaKenny Rodriguez-Wallberg500 participants
Short Versus Long-term Androgen Deprivation Therapy Combined With Salvage Radiotherapy in Prostate Cancer Patients With Biochemical Recurrence After Prostatectomy: a Multicentre Phase III Randomised Controlled TrialNCT05781217 · start 2023-03-14 · primary completion 2023-12Phase 3RecruitingProstate Cancer · Salvage Radiotherapy · Biochemical Recurrence · Androgen Deprivation Therapy · Metastases-free SurvivalInstituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic534 participants
Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)NCT05050084 · start 2021-12-06 · primary completion 2026-11-11Phase 3Active Not RecruitingProstate AdenocarcinomaNRG Oncology2050 participants
Stereotactic Prostate Radiotherapy With or Without Androgen Deprivation Therapy, a Phase III, Multi-institutional Randomized-controlled Trial. The SPA Trial.NCT05019846 · start 2021-09-30 · primary completion 2025-12-01Phase 3RecruitingProstate CancerMarco Lorenzo Bonu310 participants
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for OligoRecurrenT Prostate Cancer (VA STARPORT)NCT04787744 · start 2021-07-01 · primary completion 2026-09-30Phase 2 / Phase 3RecruitingProstate Cancer · Oligometastasis · Oligorecurrence · Recurrent Prostate Cancer · Metastatic Prostate Cancer · De Novo Prostate CancerVA Office of Research and Development464 participants
A Phase III Double Blinded Study of Early Intervention After RADICAl ProstaTEctomy With Androgen Deprivation Therapy With or Without Darolutamide vs. Placebo in Men at Highest Risk of Prostate Cancer Metastasis by Genomic Stratification (ERADICATE)NCT04484818 · start 2021-03-01 · primary completion 2026-06-09Phase 3Active Not RecruitingProstate CarcinomaECOG-ACRIN Cancer Research Group27 participants
Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate CancerNCT03678025 · start 2018-09-24 · primary completion 2028-04-01Phase 3RecruitingCastration Levels of Testosterone · Metastatic Prostatic Adenocarcinoma · Stage IV Prostate Cancer AJCC v8 · Stage IVA Prostate Cancer AJCC v8 · Stage IVB Prostate Cancer AJCC v8SWOG Cancer Research Network1273 participants
The Role of Stereotactic Body Radiotherapy in the Management of Castration-Resistant Prostate Cancer with Oligometastases: an Adaptive Phase II/III Randomized Trial.NCT02685397 · start 2016-10 · primary completion 2027-04Phase 2 / Phase 3Active Not RecruitingCastration-resistant Prostate Cancer Patients with OligometastasesSir Mortimer B. Davis - Jewish General Hospital102 participants
Randomized, Placebo-controlled, Double-blind, Single-center Trial to Evaluate the Possible Action of Resveratrol in Improving the Outcomes of Controlled Ovarian Stimulation During the IVF/ICSI Cycles in Couples With Unexplained InfertilityNCT06481696 · start 2024-06-01 · primary completion 2025-12-31Not applicableUnknownUnexplained InfertilityAndros Day Surgery Clinic90 participants
A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast CancerNCT05896566 · start 2024-01-23 · primary completion 2025-09-18Phase 2CompletedBreast CancerETOP IBCSG Partners Foundation231 participants
Treatment of Infertile Adenomyosis Patients Using Levonorgestrel-releasing Intrauterine System or Gonadotropin-releasing Hormone Agonist Before Frozen Blastocyst Transfer Improves Manifestations and Increases the Chances of PregnancyNCT06581679 · start 2023-12-15 · primary completion 2024-04-10Not applicableCompletedAdenomyosisZagazig University184 participants
Real World Evidence Study on Metastatic Prostate Cancer Patient Characteristics, Treatment Patterns and Outcomes in the Pirkanmaa Hospital District in FinlandNCT05701007 · start 2023-02-13 · primary completion 2024-04-10Not applicableCompletedMetastatic Castration Sensitive Prostate Cancer (mCSPC) · Metastatic Castration Resistant Prostate Cancer (mCRPC)Pfizer1083 participants
DEPO-Trigger Trial: GnRH Agonist DEPOt TRIGGER for Final Oocyte Maturation in Breast Cancer Patients Undergoing Fertility Preservation: a Pilot StudyNCT04616729 · start 2022-11-01 · primary completion 2025-11-30Phase 1 / Phase 2UnknownBreast Cancer FemaleUniversitair Ziekenhuis Brussel30 participants
An Open-label, Multicentre, Single Arm Study to Assess the Efficacy and Safety of Triptorelin 6-month Formulation Administered Subcutaneously in Participants With Locally Advanced and/or Metastatic Prostate Cancer Previously Treated and Castrated With a GnRH AnalogueNCT05458856 · start 2022-08-30 · primary completion 2024-07-08Phase 3CompletedProstate CancerIpsen147 participants
COMPARING TWO PROTOCOLS FOR FINAL OOCYTE MATURATION IN POOR RESPONDERS UNDERGOING GnRH-ANTAGONIST ICSI CYCLESNCT05397795 · start 2022-06-01 · primary completion 2022-12-01Phase 3UnknownInfertilityAlexandria University160 participants
Long-term Effects of Enhanced Systemic Therapy and Tumor-directed Therapy for Newly Diagnosed Oligometastatic Prostate Cancer Confirmed by Conventional Imaging Modality: a Prospective, Single-arm Study.NCT05212857 · start 2022-04 · primary completion 2024-02Phase 2UnknownProstate CancerFudan University160 participants
Double Ovarian Stimulation (DuoStim) Comparison of Triggers: Is There Any Advantage Using 3 Different Methods of Trigger for the Second Egg Collection in Predicted Low Responders?NCT05321511 · start 2022-03-03 · primary completion 2022-12-31Phase 4UnknownIVF · LOW OVARIAN RESPONSEInstituto Bernabeu165 participants
A Multicenter Randomized Clinical Trial of Mifepristone Versus GnRHa for the Treatment of AdenomyosisNCT05151016 · start 2021-12-01 · primary completion 2023-12-31Early phase 1UnknownAdenomyosis · MifepristoneWomen's Hospital School Of Medicine Zhejiang University140 participants
Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI CyclesNCT05112692 · start 2021-11 · primary completion 2023-11Not applicableUnknownPCOS (Polycystic Ovary Syndrome) of Bilateral OvariesMansoura University200 participants
A Phase III, Open-label, Multicentre, Single Arm Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Chinese Paediatric Participants With Central Precocious Puberty.NCT05029622 · start 2021-08-10 · primary completion 2022-08-21Phase 3CompletedCentral Precocious PubertyIpsen66 participants
An Open-label, Multicentre, Single Arm Study to Assess the Efficacy and Safety of Triptorelin 3-month Formulation in Chinese Children With Central Precocious PubertyNCT04736602 · start 2021-03-27 · primary completion 2022-02-09Phase 3CompletedCentral Precocious PubertyIpsen32 participants
Effect of GnRH Agonist (Long Protocol) vs GnRH Antagonist (Flexible Protocol) on Oocyte Morphology During IVF/ICSINCT04724486 · start 2020-08-22 · primary completion 2022-03-15Phase 4CompletedIn Vitro Fertilization · Intracytoplasmic Sperm Injection · InfertilityDamascus University50 participants
The Impact of Continuous Versus Intermittent Androgen Deprivation Therapy on Bone Mineral Density Change in Prostate Cancer Patients: A Multicenter, Randomized Clinical TrialNCT04248621 · start 2020-01-23 · primary completion 2022-04-30Phase 4UnknownProstatic NeoplasmsWonju Severance Christian Hospital164 participants
Effect of GnRH Agonist (Long Protocol) vs GnRH Antagonist (Flexible Protocol) on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.NCT04727671 · start 2019-12-22 · primary completion 2021-08-15Phase 4CompletedIn Vitro Fertilization · Intracytoplasmic Sperm Injection · Infertility · Polycystic Ovary SyndromeDamascus University50 participants
Effect of GnRH Agonist (Long Protocol) vs GnRH Antagonist (Flexible Protocol) on IVF/ICSI Outcomes.NCT04724343 · start 2019-12-22 · primary completion 2022-01-01Phase 4CompletedIn Vitro Fertilization · Intracytoplasmic Sperm Injection · InfertilityDamascus University50 participants
A Phase II Study Comparing Salvage Radiotherapy in Combination With 6 Months of Androgen-deprivation Therapy Versus Anti-androgen Therapy With Apalutamide in Patients With Biochemical Progression After Radical ProstatectomyNCT03899077 · start 2019-04-05 · primary completion 2025-08Phase 2UnknownCancer of ProstateCancer Research Antwerp202 participants
The Effectiveness and Safety of the Early Follicular Phase Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation: a Randomized, Paralleled, Controlled, Multicenter TrialNCT03809221 · start 2019-02-01 · primary completion 2020-09-01Phase 4UnknownInfertility, FemalePeking University People's Hospital1892 participants
A Prospective, Randomized, Open Study on the Efficacy and Safety of the GnRH Analogue Triptorelin for HIV-1 Reservoir Reduction in ART Treated HIV-1 Infected PatientsNCT03536234 · start 2018-09-19 · primary completion 2021-08Phase 2UnknownHIV-1-infectionImmune System Regulation AB52 participants
A Phase III, Multicentre, Randomised, Open-label, Parallel, Active-controlled Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With EndometriosisNCT03232281 · start 2017-07-28 · primary completion 2019-05-17Phase 3CompletedEndometriosisIpsen300 participants
Is Early Preparation With GnRh Agonists Injection on D-1 of Menses of Hormonal Replacement Cycle Improves Pregnancy Rate in Women With Impaired Ovulation and Undergoing Frozen-Thawed Embryo Transfer? A Randomized Controlled StudyNCT03353883 · start 2017-06-01 · primary completion 2018-06Phase 2 / Phase 3UnknownInfertility, FemaleBenha University200 participants

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

  1. Human study · PubMed trial index

    A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty.

    Yu X, Cheng X, Wei H et al. · Advances in therapy · 2024

    PMID 39412628 · DOI: 10.1007/s12325-024-02991-x

  2. Human study · PubMed trial index

    Efficacy and safety of triptorelin 6-month formulation in patients with central precocious puberty.

    Klein K, Yang J, Aisenberg J et al. · Journal of pediatric endocrinology & metabolism : JPEM · 2016

    PMID 26887034 · DOI: 10.1515/jpem-2015-0376

  3. Human study · PubMed trial index

    Comparison of dienogest versus triptorelin acetate in premenopausal women with adenomyosis: a prospective clinical trial.

    Fawzy M, Mesbah Y · Archives of gynecology and obstetrics · 2015

    PMID 25990480 · DOI: 10.1007/s00404-015-3755-5

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Research publication · design requires review

    Cost-Effectiveness Analysis of Triptorelin, Goserelin, and Leuprolide in the Treatment of Patients With Metastatic Prostate Cancer: A Societal Perspective.

    Rezaee M, Karimzadeh I, Hashemi-Meshkini A et al. · Value in health regional issues · 2024

    PMID 38663058 · DOI: 10.1016/j.vhri.2024.01.004

  2. Review · secondary evidence

    Unveiling the Effects of Triptorelin on Endocrine Profiles: Insights From Healthy, Polycystic Ovary Syndrome, and Hypothalamic Amenorrhea Women.

    Kumari R, Muneshwar KN, Pathade AG et al. · Cureus · 2023

    PMID 37809244 · DOI: 10.7759/cureus.44752

  3. Review · secondary evidence

    Triptorelin for the treatment of endometriosis.

    Leone Roberti Maggiore U, Scala C, Remorgida V et al. · Expert opinion on pharmacotherapy · 2014

    PMID 24832495 · DOI: 10.1517/14656566.2014.916279

Triptorelin supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Triptorelin for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Cenexa LabsUSD2mg Vial1 recorded offers2mg Vial · $59.99Checked Oct 7, 2026Supplier listing

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

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Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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