Skip to content
PeptideTech
sign in
live116 compounds · 15 vendors listed · 7 graded · audit of 4 Nov 2026 · prices checked 6 Nov 2026independent · grades can’t be bought

Home / Research library / Acetyl Hexapeptide-3 (Argireline)

Peptides

Acetyl Hexapeptide-3 (Argireline): molecular data, studies & sources

Acetyl Hexapeptide-3 (Argireline) is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C35H62N14O11S
Molecular weight (MW)
887.0 g/mol
PubChem compound ID
71587772
Record title
Acetyl hexapeptide-3

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 71587772 · retrieved 2026-09-21

2D molecular structure for Acetyl Hexapeptide-3 (Argireline), PubChem CID 71587772
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
AJLNZWYOJAWBCR-OOPVGHQCSA-N
SMILES
CC(=O)N[C@@H](CCC(=O)O)C(=C)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
71587772
CAS Registry Number
616204-22-9via ChemIDplus, EPA DSSTox
InChIKey
AJLNZWYOJAWBCR-OOPVGHQCSA-N

Peptide sequence · 5 residues (one-letter code; X marks a residue without a one-letter code)

EMQRR

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass886.4443 Da
Heavy atoms61
Hydrogen-bond donors14
Hydrogen-bond acceptors13
Rotatable bonds33
Topological polar surface area447.1 Ų
Calculated logP (Crippen)-4.76
Rings0
Stereocenters6
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Acetyl hexapeptide-8 as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

3 registered studies matched, 2 with results posted on ClinicalTrials.gov.

By highest phase
Phase 2 · 2Not applicable · 1
By registry status
Completed · 2Terminated · 1
StudyPhase · statusConditionsSponsor · size
Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily SkinNCT02597777 · start 2016-01 · primary completion 2016-02Not applicableCompletedOily SkinUniversity of California, Davis14 participants
Acetyl Hexapeptide-8 for BlepharospasmNCT01750346 · start 2012-11 · primary completion 2015-05Phase 2TerminatedResults posted 2016-11-10Focal DystoniaNational Institute of Neurological Disorders and Stroke (NINDS)8 participants
A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of BlepharospasmNCT00942851 · start 2009-07 · primary completion 2010-10Phase 1 / Phase 2CompletedResults posted 2012-09-06Focal DystoniaNational Institute of Neurological Disorders and Stroke (NINDS)24 participants

Registry check 2026-10-09 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Acetyl hexapeptide-8, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.

    Lungu C, Considine E, Zahir S et al. · European journal of neurology · 2013

    PMID 23146065 · DOI: 10.1111/ene.12009

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Review · secondary evidence

    Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy.

    Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M et al. · International journal of molecular sciences · 2025

    PMID 40565185 · DOI: 10.3390/ijms26125722

  2. Research publication · design requires review

    Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.

    Olsson SE, Sreepad B, Lee T et al. · JMIR dermatology · 2024

    PMID 38376906 · DOI: 10.2196/54217

  3. Research publication · design requires review

    Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics.

    Johnson W, Bergfeld WF, Belsito DV et al. · International journal of toxicology · 2025

    PMID 40673537 · DOI: 10.1177/10915818251340391

  4. Research publication · design requires review

    Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.

    Velazco de Maldonado GJ, Suárez-Vega DV, Miller-Kobisher B et al. · Journal of cutaneous and aesthetic surgery · 2023

    PMID 38314369 · DOI: 10.4103/JCAS.JCAS_34_23

  5. Preclinical / laboratory research

    Topical delivery of acetyl hexapeptide-8 from different emulsions: influence of emulsion composition and internal structure.

    Hoppel M, Reznicek G, Kählig H et al. · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2015

    PMID 25497319 · DOI: 10.1016/j.ejps.2014.12.006

Acetyl Hexapeptide-3 (Argireline) supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Acetyl Hexapeptide-3 (Argireline) for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Cenexa LabsUSD200mg Powder1 recorded offers200mg Powder · $209.99Checked Nov 6, 2026Supplier listing, Acetyl Hexapeptide-3 (Argireline) 200mg Powder, Cenexa Labs, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

Related research profiles