Peptides

Matrixyl: molecular data, studies & sources

Matrixyl is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked 2026-10-09 · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF): C39H75N7O10
Molecular weight (MW): 802.1 g/mol
PubChem compound ID: 9897237
Record title: Palmitoyl Pentapeptide-4

Matrixyl 3000 is a different combination (palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7).

Source: PubChem CID 9897237 · retrieved 2026-10-09

2D molecular structure for Matrixyl, PubChem CID 9897237 — 2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.

Chemical identifiers and source data

IUPAC name: (2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid
InChIKey: WSGCRSMLXFHGRM-DEVHWETNSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O

Machine-readable PubChem source

Identifiers & sequence

PubChem CID: 9897237
CAS Registry Number: 214047-00-4via EPA DSSTox
ChEMBL ID: CHEMBL451881
InChIKey: WSGCRSMLXFHGRM-DEVHWETNSA-N
Wikidata: Q18386276

Peptide sequence · 5 residues (one-letter code; X marks a residue without a one-letter code)

KTTKS

Condensed notation with terminal groups and non-standard residues

palmitoyl-Lys-Thr-Thr-Lys-Ser-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-09.

Calculated molecular descriptors

Monoisotopic (exact) mass	801.5575 Da
Heavy atoms	56
Hydrogen-bond donors	11
Hydrogen-bond acceptors	11
Rotatable bonds	35
Topological polar surface area	295.5 Å²
Calculated logP (Crippen)	0.99
Rings	0
Stereocenters	7
Formal charge	0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Matrixyl as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Matrixyl, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

Research publication · design requires review
Liposome Encapsulation of the Palmitoyl-KTTKS Peptide: Structural and Functional Characterization.
Vitali A, Paolicelli P, Bigi B et al. · Pharmaceutics · 2024
PMID 38399273 · DOI: 10.3390/pharmaceutics16020219
Research publication · design requires review
Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing.
Kachooeian M, Mousivand Z, Sharifikolouei E et al. · ACS omega · 2022
PMID 35874243 · DOI: 10.1021/acsomega.2c02592
Research publication · design requires review
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS).
Choi YL, Park EJ, Kim E et al. · Biomolecules & therapeutics · 2014
PMID 25143811 · DOI: 10.4062/biomolther.2014.053
Research publication · design requires review
Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.
Aruan RR, Hutabarat H, Widodo AA et al. · The Journal of clinical and aesthetic dermatology · 2023
PMID 36909866

Matrixyl supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

No priced supplier offers are currently available in this catalog view. The research record remains available independently of stock.

Reference sources & further reading

PubChem compound record 9897237 — chemical identity and structure.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.