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Home / Research library / Kisspeptin-10

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Kisspeptin-10: molecular data, studies & sources

Kisspeptin-10 is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C63H83N17O14
Molecular weight (MW)
1302.4 g/mol
PubChem compound ID
25240297
Record title
Kisspeptin-10

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 25240297 · retrieved 2026-09-21

2D molecular structure for Kisspeptin-10, PubChem CID 25240297
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide
InChIKey
RITKWYDZSSQNJI-INXYWQKQSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
25240297
CAS Registry Number
374675-21-5via ChemIDplus, FDA GSRS
FDA UNII
FS1N52VS3S
ChEMBL ID
CHEMBL376756
InChIKey
RITKWYDZSSQNJI-INXYWQKQSA-N

Peptide sequence · 10 residues (one-letter code; X marks a residue without a one-letter code)

YNWNSFGLRF

Condensed notation with terminal groups and non-standard residues

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass1301.6305 Da
Heavy atoms94
Hydrogen-bond donors18
Hydrogen-bond acceptors16
Rotatable bonds38
Topological polar surface area537.8 Ų
Calculated logP (Crippen)-4.21
Rings5
Stereocenters9
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

US regulatory status & drug development

Drug development record (ChEMBL)

Harmonized drug-development record from ChEMBL. The highest clinical stage is the furthest stage reached, as recorded by ChEMBL; it can lag regulatory approvals, and it is not an approval of a research-supplier product.

ChEMBL ID
CHEMBL376756
Modality
Protein / peptide
Highest clinical stage
Phase 3
Record name
KISSPEPTIN-10

Identity check: Identical standard InChIKey to the PubChem record. Source: ChEMBL CHEMBL376756 (EMBL-EBI, CC BY-SA 3.0) · retrieved 2026-10-07

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Kisspeptin-10 as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

5 registered studies matched.

By highest phase
Phase 3 · 3Phase 1 · 2
By registry status
Completed · 3Withdrawn · 2
StudyPhase · statusConditionsSponsor · size
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic ClampNCT05456854 · start 2022-06-03 · primary completion 2024-08-01Phase 1WithdrawnWhy stopped: FutilityMetabolic DiseaseMassachusetts General HospitalEnrollment not listed
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal ToleranceNCT04532801 · start 2019-09-01 · primary completion 2024-08-31Phase 1WithdrawnWhy stopped: Interim analysis of data collected under other clinical trials demonstrated planned enrollment was insufficiently powered.Insulin · Glucose · Healthy Volunteers · Women · PregnancyStephanie B. Seminara, MDEnrollment not listed
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in MenNCT03315325 · start 2014-08-08 · primary completion 2014-08-10Phase 3CompletedSterility, ReproductiveQuaid-e-Azam University15 participants
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.NCT03286517 · start 2014-06-26 · primary completion 2014-08-08Phase 3CompletedReproductive Physiological PhenomenaGhulam Nabi30 participants
KP-10 and Insulin Secretion in MenNCT03771326 · start 2013-10-29 · primary completion 2013-11-04Phase 3CompletedKisspeptin Action on Insulin in Healthy Normal Men · Kisspeptin Action on Insulin in Obese Diabetic MenQuaid-e-Azam University14 participants

Registry check 2026-10-09 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Kisspeptin-10, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

    George JT, Veldhuis JD, Roseweir AK et al. · The Journal of clinical endocrinology and metabolism · 2011

    PMID 21632807 · DOI: 10.1210/jc.2011-0089

  2. Human study · PubMed trial index Compound given to participants

    Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism.

    George JT, Veldhuis JD, Tena-Sempere M et al. · Clinical endocrinology · 2013

    PMID 23153270 · DOI: 10.1111/cen.12103

  3. Human study · PubMed trial index Compound given to participants

    Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.

    Ullah H, Nabi G, Zubair H et al. · Andrologia · 2019

    PMID 30590872 · DOI: 10.1111/and.13219

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Preclinical / laboratory research

    Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

    Li Z, Yang X, Fu R et al. · Nature communications · 2024

    PMID 38346942 · DOI: 10.1038/s41467-024-44852-9

  2. Research publication · design requires review

    Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

    Li Z, Yang X, Fu R et al. · Nature communications · 2024

    PMID 39702286 · DOI: 10.1038/s41467-024-55352-1

Kisspeptin-10 supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Kisspeptin-10 for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $65.00Stale observation · Checked Sep 30, 2026Supplier listing, Kisspeptin-10 10mg Vial, Blank Peptides, opens in a new tab
American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $60.00Checked Nov 6, 2026Supplier listing, Kisspeptin-10 10mg Vial, American Peptides, opens in a new tab
Amino ClubUSD10mg Vial1 recorded offers10mg Vial · $49.99Stale observation · Checked Oct 14, 2026Supplier listing, Kisspeptin-10 10mg Vial, Amino Club, opens in a new tab
Amino USAUSD10mg Vial · 5mg Vial2 recorded offers10mg Vial · $100.00Checked Nov 6, 2026Supplier listing, Kisspeptin-10 10mg Vial, Amino USA, opens in a new tab
Cenexa LabsUSD10mg Vial1 recorded offers10mg Vial · $59.99Checked Nov 6, 2026Supplier listing, Kisspeptin-10 10mg Vial, Cenexa Labs, opens in a new tab
LA PeptidesUSD10mg Vial1 recorded offers10mg Vial · $59.99Checked Nov 3, 2026Supplier listing, Kisspeptin-10 10mg Vial, LA Peptides, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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