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KPV: molecular data, studies & sources

KPV is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C16H30N4O4
Molecular weight (MW)
342.43 g/mol
PubChem compound ID
125672
Record title
Msh (11-13)

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 125672 · retrieved 2026-09-21

2D molecular structure for KPV, PubChem CID 125672
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
InChIKey
YSPZCHGIWAQVKQ-AVGNSLFASA-N
SMILES
CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
Machine-readable PubChem source
Calculated molecular descriptors
Monoisotopic (exact) mass342.2267 Da
Heavy atoms24
Hydrogen-bond donors4
Hydrogen-bond acceptors5
Rotatable bonds9
Topological polar surface area138.8 Ų
Calculated logP (Crippen)-0.34
Rings1
Stereocenters3
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list KPV as an intervention. Studies that only measure the molecule as a biomarker are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

No matching human study was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

    Preclinical research, reviews & other publications

    Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

    1. Research publication · design requires review

      alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.

      Elliott RJ, Szabo M, Wagner MJ et al. · The Journal of investigative dermatology · 2004

      PMID 15102092 · DOI: 10.1111/j.0022-202X.2004.22404.x

    2. Preclinical / laboratory research

      A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.

      Zhao Y, Xue P, Lin G et al. · Acta biomaterialia · 2022

      PMID 35245681 · DOI: 10.1016/j.actbio.2022.02.039

    3. Research publication · design requires review

      Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.

      Pawar K, Kolli CS, Rangari VK et al. · Journal of pharmaceutical sciences · 2017

      PMID 28343991 · DOI: 10.1016/j.xphs.2017.03.017

    4. Preclinical / laboratory research

      Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.

      Getting SJ, Schiöth HB, Perretti M et al. · The Journal of pharmacology and experimental therapeutics · 2003

      PMID 12750433 · DOI: 10.1124/jpet.103.051623

    5. Research publication · design requires review

      KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.

      Zhang L, Li D, Aierken Y et al. · Advanced healthcare materials · 2024

      PMID 39252648 · DOI: 10.1002/adhm.202402320

    6. Research publication · design requires review

      PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.

      Dalmasso G, Charrier-Hisamuddin L, Nguyen HT et al. · Gastroenterology · 2007

      PMID 18061177 · DOI: 10.1053/j.gastro.2007.10.026

    7. Preclinical / laboratory research

      Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.

      Kannengiesser K, Maaser C, Heidemann J et al. · Inflammatory bowel diseases · 2008

      PMID 18092346 · DOI: 10.1002/ibd.20334

    8. Preclinical / laboratory research

      Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.

      Sun J, Xue P, Liu J et al. · ACS biomaterials science & engineering · 2021

      PMID 34547895 · DOI: 10.1021/acsbiomaterials.1c00792

    KPV supplier sources

    Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

    KPV for sale: compare prices, sizes and forms from every tracked supplier →

    SupplierRecorded packagesExample source listing
    American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $60.00Checked Oct 7, 2026Supplier listing
    Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $45.00Stale observation · Checked Sep 30, 2026Supplier listing
    Amino ClubUSD10mg Vial1 recorded offers10mg Vial · $39.99Stale observation · Checked Sep 28, 2026Supplier listing
    Nova Peptide SupplyUSD10mg Vial1 recorded offers10mg Vial · $49.99Checked Oct 6, 2026Supplier listing
    Amino USAUSD10mg Vial · 5mg Vial2 recorded offers10mg Vial · $50.00Checked Oct 7, 2026Supplier listing
    Cenexa LabsUSD10mg Vial1 recorded offers10mg Vial · $69.99Checked Oct 7, 2026Supplier listing

    Reference sources & further reading

    The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

    Search for additional research

    These links run searches; their results have not been individually reviewed and can include unrelated compounds.

    Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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