KPV: molecular data, studies & sources

Molecular formula, weight & structure

Molecular formula (MF)

C16H30N4O4

Molecular weight (MW)

342.43 g/mol

PubChem compound ID

125672

Record title

Msh (11-13)

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 125672 · retrieved 2026-09-21

Registered clinical trials

Studies registered on ClinicalTrials.gov that list KPV as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received KPV, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

1. Research publication · design requires review

   alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.

   Elliott RJ, Szabo M, Wagner MJ et al. · The Journal of investigative dermatology · 2004

   PMID 15102092 · DOI: 10.1111/j.0022-202X.2004.22404.x

2. Preclinical / laboratory research

   A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.

   Zhao Y, Xue P, Lin G et al. · Acta biomaterialia · 2022

   PMID 35245681 · DOI: 10.1016/j.actbio.2022.02.039

3. Research publication · design requires review

   Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.

   Pawar K, Kolli CS, Rangari VK et al. · Journal of pharmaceutical sciences · 2017

   PMID 28343991 · DOI: 10.1016/j.xphs.2017.03.017

4. Preclinical / laboratory research

   Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.

   Getting SJ, Schiöth HB, Perretti M et al. · The Journal of pharmacology and experimental therapeutics · 2003

   PMID 12750433 · DOI: 10.1124/jpet.103.051623

5. Research publication · design requires review

   KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.

   Zhang L, Li D, Aierken Y et al. · Advanced healthcare materials · 2024

   PMID 39252648 · DOI: 10.1002/adhm.202402320

6. Research publication · design requires review

   PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.

   Dalmasso G, Charrier-Hisamuddin L, Nguyen HT et al. · Gastroenterology · 2007

   PMID 18061177 · DOI: 10.1053/j.gastro.2007.10.026

7. Preclinical / laboratory research

   Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.

   Kannengiesser K, Maaser C, Heidemann J et al. · Inflammatory bowel diseases · 2008

   PMID 18092346 · DOI: 10.1002/ibd.20334

8. Preclinical / laboratory research

   Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.

   Sun J, Xue P, Liu J et al. · ACS biomaterials science & engineering · 2021

   PMID 34547895 · DOI: 10.1021/acsbiomaterials.1c00792

KPV supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

KPV for sale: compare prices, sizes and forms from every tracked supplier →

Reference sources & further reading

• PubChem compound record 125672 — chemical identity and structure.
• Wikipedia: KPV tripeptide — Background encyclopedia; not a primary clinical source.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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