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Home / Research library / Melanotan-2

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Melanotan-2: molecular data, studies & sources

Melanotan-2 is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C50H69N15O9
Molecular weight (MW)
1024.2 g/mol
PubChem compound ID
92432
Record title
melanotan-II

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 92432 · retrieved 2026-09-21

2D molecular structure for Melanotan-2, PubChem CID 92432
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
SMILES
CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
92432
CAS Registry Number
121062-08-6via ChemIDplus, EPA DSSTox, FDA GSRS
FDA UNII
UPF5CJ93X7
ChEMBL ID
CHEMBL430239
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
Wikidata
Q423855

Peptide sequence · 7 residues (one-letter code; X marks a residue without a one-letter code)

XDHFRWK

Condensed notation with terminal groups and non-standard residues

Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass1023.5403 Da
Heavy atoms74
Hydrogen-bond donors13
Hydrogen-bond acceptors11
Rotatable bonds17
Topological polar surface area384.8 Ų
Calculated logP (Crippen)-1.25
Rings5
Stereocenters7
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Melanotan-2 as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

1 registered study matched, 1 currently active or recruiting.

By highest phase
Phase 2 · 1
By registry status
Recruiting · 1
StudyPhase · statusConditionsSponsor · size
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoNCT07437560 · start 2026-02-02 · primary completion 2027-02-14Phase 2RecruitingNonSegmental Vitiligo · Nonsegmental Vitiligo (Stable)Hudson Biotech60 participants

Registry check 2026-10-09 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Melanotan-2, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.

    Dorr RT, Lines R, Levine N et al. · Life sciences · 1996

    PMID 8637402 · DOI: 10.1016/0024-3205(96)00160-9

  2. Human study · PubMed trial index Compound given to participants

    Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.

    Wessells H, Levine N, Hadley ME et al. · International journal of impotence research · 2000

    PMID 11035391 · DOI: 10.1038/sj.ijir.3900582

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Review · secondary evidence

    Melanotan II: a possible cause of renal infarction: review of the literature and case report.

    Peters B, Hadimeri H, Wahlberg R et al. · CEN case reports · 2020

    PMID 31953620 · DOI: 10.1007/s13730-020-00447-z

Melanotan-2 supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Melanotan-2 for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $40.00Stale observation · Checked Sep 30, 2026Supplier listing, Melanotan-2 10mg Vial, Blank Peptides, opens in a new tab
American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $55.00Checked Nov 6, 2026Supplier listing, Melanotan-2 10mg Vial, American Peptides, opens in a new tab
Amino ClubUSD10mg Vial · 15mg Spray2 recorded offers10mg Vial · $29.95Stale observation · Checked Oct 14, 2026Supplier listing, Melanotan-2 10mg Vial, Amino Club, opens in a new tab
Nova Peptide SupplyUSD10mg Vial1 recorded offers10mg Vial · $34.99Checked Nov 6, 2026Supplier listing, Melanotan-2 10mg Vial, Nova Peptide Supply, opens in a new tab
Amino USAUSD10mg Vial1 recorded offers10mg Vial · $30.00Checked Nov 6, 2026Supplier listing, Melanotan-2 10mg Vial, Amino USA, opens in a new tab
Cenexa LabsUSD10mg Vial1 recorded offers10mg Vial · $44.99Checked Nov 6, 2026Supplier listing, Melanotan-2 10mg Vial, Cenexa Labs, opens in a new tab
LA PeptidesUSD10mg Spray · 10mg Vial2 recorded offers10mg Spray · $59.99Checked Nov 3, 2026Supplier listing, Melanotan-2 10mg Spray, LA Peptides, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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