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Bioregulators · Peptides

Pancragen: molecular data, studies & sources

Pancragen is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C26H36N6O9
Molecular weight (MW)
576.6 g/mol
PubChem compound ID
68452877
Record title
H-Lys-Glu-Asp-Trp-OH

This source structure is Lys-Glu-Asp-Trp (KEDW), the sequence identified as Pancragen in PMID 22808515. The formula describes this specific unmodified peptide record, not a vendor batch.

Source: PubChem CID 68452877 · retrieved 2026-09-21 · Identity cross-reference

2D molecular structure for Pancragen, PubChem CID 68452877
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(4S)-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoic acid
InChIKey
PIGJHNNSOMRLST-LEAZDLGRSA-N
SMILES
C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
68452877
InChIKey
PIGJHNNSOMRLST-LEAZDLGRSA-N

Peptide sequence · 4 residues (one-letter code; X marks a residue without a one-letter code)

KEDW

Condensed notation with terminal groups and non-standard residues

H-Lys-Glu-Asp-Trp-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

Calculated molecular descriptors
Monoisotopic (exact) mass576.2544 Da
Heavy atoms41
Hydrogen-bond donors9
Hydrogen-bond acceptors8
Rotatable bonds18
Topological polar surface area267.0 Ų
Calculated logP (Crippen)-0.95
Rings2
Stereocenters4
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Pancragen as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Pancragen, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

    Preclinical research, reviews & other publications

    Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

    1. Research publication · design requires review

      Effects of pancragen on the differentiation of pancreatic cells during their ageing.

      Khavinson VKh, Durnova AO, Polyakova VO et al. · Bulletin of experimental biology and medicine · 2013

      PMID 23486591 · DOI: 10.1007/s10517-013-1987-6

    2. Preclinical / laboratory research

      [Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys].

      Goncharova ND, Ivanova LG, Oganyan TE et al. · Advances in gerontology = Uspekhi gerontologii · 2015

      PMID 28509500

    3. Preclinical / laboratory research

      Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus.

      Khavinson VKh, Gavrisheva NA, Malinin VV et al. · Bulletin of experimental biology and medicine · 2007

      PMID 18642713 · DOI: 10.1007/s10517-007-0377-3

    4. Preclinical / laboratory research

      Peptides tissue-specifically stimulate cell differentiation during their aging.

      Khavinson VKh, Linkova NS, Polyakova VO et al. · Bulletin of experimental biology and medicine · 2012

      Experiments in cultured human-derived cells. Human cell culture is not a clinical trial in people.

      PMID 22808515 · DOI: 10.1007/s10517-012-1664-1

    5. Preclinical / laboratory research

      [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].

      Zakutskiĭ AN, Chalisova NI, Ryzhak GA et al. · Advances in gerontology = Uspekhi gerontologii · 2006

      Organotypic tissue cultures from young and aged rats. Tissue-culture responses do not demonstrate patient benefit.

      PMID 17152728

    Pancragen supplier sources

    Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

    Pancragen for sale: compare prices, sizes and forms from every tracked supplier →

    SupplierRecorded packagesExample source listing
    Cenexa LabsUSD20mg Vial1 recorded offers20mg Vial · $64.99Checked Oct 13, 2026Supplier listing, Pancragen 20mg Vial, Cenexa Labs, opens in a new tab

    Reference sources & further reading

    The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

    Search for additional research

    These links run searches; their results have not been individually reviewed and can include unrelated compounds.

    Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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