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Home / Research library / Pentapeptide-18 (Leuphasyl)

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Pentapeptide-18 (Leuphasyl): molecular data, studies & sources

Pentapeptide-18 (Leuphasyl) is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C29H39N5O7
Molecular weight (MW)
569.6 g/mol
PubChem compound ID
10099522
Record title
Pentapeptide-18

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 10099522 · retrieved 2026-09-21

2D molecular structure for Pentapeptide-18 (Leuphasyl), PubChem CID 10099522
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
InChIKey
ZHUJMSMQIPIPTF-JMBSJVKXSA-N
SMILES
C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
10099522
CAS Registry Number
64963-01-5via ChemIDplus, EPA DSSTox, FDA GSRS
FDA UNII
PO4D55T1IG
ChEMBL ID
CHEMBL4539258
InChIKey
ZHUJMSMQIPIPTF-JMBSJVKXSA-N

Other names and development codes: NSC-374895

Peptide sequence · 5 residues (one-letter code; X marks a residue without a one-letter code)

YAGFL

Condensed notation with terminal groups and non-standard residues

H-Tyr-D-Ala-Gly-Phe-Leu-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass569.2849 Da
Heavy atoms41
Hydrogen-bond donors7
Hydrogen-bond acceptors7
Rotatable bonds15
Topological polar surface area199.9 Ų
Calculated logP (Crippen)0.23
Rings2
Stereocenters4
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Pentapeptide-18 as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Pentapeptide-18, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

    Preclinical research, reviews & other publications

    Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

    1. Research publication · design requires review

      Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18-Optimization, Characterization, and Cosmetic Application.

      Pawłowska M, Marzec M, Jankowiak W et al. · International journal of molecular sciences · 2024

      PMID 39337562 · DOI: 10.3390/ijms251810078

    2. Research publication · design requires review

      Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis.

      Akhan D, Bicak B, Akalin E et al. · Computational biology and chemistry · 2026

      PMID 41722287 · DOI: 10.1016/j.compbiolchem.2026.108952

    Pentapeptide-18 (Leuphasyl) supplier sources

    Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

    Pentapeptide-18 (Leuphasyl) for sale: compare prices, sizes and forms from every tracked supplier →

    SupplierRecorded packagesExample source listing
    Cenexa LabsUSD200mg Powder1 recorded offers200mg Powder · $209.99Checked Nov 6, 2026Supplier listing, Pentapeptide-18 (Leuphasyl) 200mg Powder, Cenexa Labs, opens in a new tab

    Reference sources & further reading

    The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

    Search for additional research

    These links run searches; their results have not been individually reviewed and can include unrelated compounds.

    Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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