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Bioregulators · Peptides

Thymogen: molecular data, studies & sources

Thymogen is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C16H19N3O5
Molecular weight (MW)
333.34 g/mol
PubChem compound ID
100094
Record title
Thymogen

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 100094 · retrieved 2026-09-21

2D molecular structure for Thymogen, PubChem CID 100094
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(4S)-4-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
InChIKey
LLEUXCDZPQOJMY-AAEUAGOBSA-N
SMILES
C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
100094
CAS Registry Number
38101-59-6via ChemIDplus, EPA DSSTox, FDA GSRS
FDA UNII
4RHY598T5U
ChEMBL ID
CHEMBL2111029
InChIKey
LLEUXCDZPQOJMY-AAEUAGOBSA-N
Wikidata
Q4457491

Other names and development codes: Oglufanide · NSC-334073

Peptide sequence · 2 residues (one-letter code; X marks a residue without a one-letter code)

EW

Condensed notation with terminal groups and non-standard residues

H-Glu-Trp-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass333.1325 Da
Heavy atoms24
Hydrogen-bond donors5
Hydrogen-bond acceptors4
Rotatable bonds8
Topological polar surface area145.5 Ų
Calculated logP (Crippen)0.47
Rings2
Stereocenters2
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

US regulatory status & drug development

Drug development record (ChEMBL)

Harmonized drug-development record from ChEMBL. The highest clinical stage is the furthest stage reached, as recorded by ChEMBL; it can lag regulatory approvals, and it is not an approval of a research-supplier product.

ChEMBL ID
CHEMBL2111029
Modality
Small molecule
Highest clinical stage
Phase 3
Record name
OGLUFANIDE
Synonyms, codes and trade names
Synonyms and development codes
NSC-334073 · Oglufanide

Identity check: Identical standard InChIKey to the PubChem record. Source: ChEMBL CHEMBL2111029 (EMBL-EBI, CC BY-SA 3.0) · retrieved 2026-10-07

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Thymogen as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Thymogen, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

  1. Human study · PubMed trial index Compound given to participants

    [Application thymogen for preoperative preparation of elderly patients with tumor processes in abdominal cavity].

    Smirnov VS, Petlenko SV, El'tsin SS et al. · Advances in gerontology = Uspekhi gerontologii · 2011

    PMID 21957588

  2. Human study · PubMed trial index Compound given to participants

    [Thymogen in the complex treatment of inflammatory diseases of the female genital system].

    Tsvelev IuV, Khavinson VKh, Diachuk AV et al. · Akusherstvo i ginekologiia · 1992

    PMID 1476231

  3. Human study · PubMed trial index Compound given to participants

    [Changes of immune and non-specific reactivity in patients with chronic suppurative obstructive bronchitis in comprehensive treatment with thymogen].

    Litvinova NV, Eremeev VV, Abramova ZP et al. · Problemy tuberkuleza · 1994

    PMID 7984617

  4. Human study · PubMed trial index Compound given to participants

    [The effect of thymogen on the state of immunity in destructive pulmonary tuberculosis].

    Medus AI, Pisarevskaia LI, Nikishina EV et al. · Voenno-meditsinskii zhurnal · 1999

    PMID 10605346

  5. Human study · PubMed trial index Compound given to participants

    [Applications of immunomodulators in complex of treatment of the soft tissue purulent wounds].

    Potiĭ VV · Klinichna khirurhiia · 2000

    PMID 11247420

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Review · secondary evidence

    The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.

    Deigin V, Linkova N, Vinogradova J et al. · International journal of molecular sciences · 2024

    PMID 38732260 · DOI: 10.3390/ijms25095042

  2. Research publication · design requires review

    Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

    Avolio F, Martinotti S, Khavinson VK et al. · International journal of molecular sciences · 2022

    PMID 35408963 · DOI: 10.3390/ijms23073607

  3. Review · secondary evidence

    Synthetic and natural immunomodulators acting as interferon inducers.

    Silin DS, Lyubomska OV, Ershov FI et al. · Current pharmaceutical design · 2009

    PMID 19355963 · DOI: 10.2174/138161209787846847

Thymogen supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Thymogen for sale: compare prices, sizes and forms from every tracked supplier →

SupplierRecorded packagesExample source listing
Amino USAUSD20mg Vial1 recorded offers20mg Vial · $45.00Checked Nov 6, 2026Supplier listing, Thymogen 20mg Vial, Amino USA, opens in a new tab

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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