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Humanin: molecular data, studies & sources

Humanin is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C119H204N34O32S2
Molecular weight (MW)
2687.2 g/mol
PubChem compound ID
16131438
Record title
Humanin

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 16131438 · retrieved 2026-09-21

2D molecular structure for Humanin, PubChem CID 16131438
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
(4S)-5-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-1-carboxyethyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
InChIKey
DPEUWKZJZIPZKE-OFANTOPUSA-N
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCSC)N
Machine-readable PubChem source

Identifiers & sequence

PubChem CID
16131438
CAS Registry Number
330936-69-1via ChemIDplus, EPA DSSTox
ChEMBL ID
CHEMBL4447799
InChIKey
DPEUWKZJZIPZKE-OFANTOPUSA-N

Peptide sequence · 24 residues (one-letter code; X marks a residue without a one-letter code)

MAPRGFSCLLLLTSEIDLPVKRRA

Condensed notation with terminal groups and non-standard residues

H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH

Source: PubChem Biologic Line Notation. A reference sequence for the record, not an analysis of a supplied batch.

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-07.

Calculated molecular descriptors
Monoisotopic (exact) mass2685.4822 Da
Heavy atoms187
Hydrogen-bond donors39
Hydrogen-bond acceptors36
Rotatable bonds88
Topological polar surface area1062.1 Ų
Calculated logP (Crippen)-8.29
Rings3
Stereocenters25
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list Humanin as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received Humanin, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

    Human studies that measured Humanin or used it as a comparator

    Indexed as human studies in PubMed, but participants were not given Humanin as the studied intervention, or the record does not establish that they were. They describe measurements or comparisons, not the effect of administering the compound.

    1. Human study · PubMed trial index Endogenous level measured · not given

      Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.

      Basereh A, Khoramipour K, Hosseini N et al. · Scientific reports · 2025

      PMID 41249265 · DOI: 10.1038/s41598-025-23914-y

    Preclinical research, reviews & other publications

    Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

    No additional matching publication was retained. The search links below allow further investigation; they are not evidence that a study exists.

      Humanin supplier sources

      Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

      Humanin for sale: compare prices, sizes and forms from every tracked supplier →

      SupplierRecorded packagesExample source listing
      Amino USAUSD10mg Vial1 recorded offers10mg Vial · $85.00Checked Oct 13, 2026Supplier listing, Humanin 10mg Vial, Amino USA, opens in a new tab
      Cenexa LabsUSD10mg Vial1 recorded offers10mg Vial · $149.99Checked Oct 13, 2026Supplier listing, Humanin 10mg Vial, Cenexa Labs, opens in a new tab
      American PeptidesUSD10mg Vial1 recorded offers10mg Vial · $150.00Recorded out of stock · Checked Oct 13, 2026Supplier listing, Humanin 10mg Vial, American Peptides, opens in a new tab

      Reference sources & further reading

      The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

      Search for additional research

      These links run searches; their results have not been individually reviewed and can include unrelated compounds.

      Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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