Peptides

MOTS-c: molecular data, studies & sources

MOTS-c is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked 2026-09-21 · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF): C101H152N28O22S2
Molecular weight (MW): 2174.6 g/mol
PubChem compound ID: 146675088
Record title: Mots-c

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 146675088 · retrieved 2026-09-21

PubChem 2D molecular structure for MOTS-c, CID 146675088 — 2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.

Chemical identifiers and source data

IUPAC name: (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
InChIKey: WYTHCOXVWRKRAH-LOKRTKBUSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N

Machine-readable PubChem source

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

Human study · PubMed trial index
Circulating levels of MOTS-c in patients with breast cancer treated with metformin.
Cuyàs E, Verdura S, Martin-Castillo B et al. · Aging · 2022
PMID 36490309 · DOI: 10.18632/aging.204423
Human study · PubMed trial index
Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.
Dieli-Conwright CM, Sami N, Norris MK et al. · Scientific reports · 2021
PMID 34413391 · DOI: 10.1038/s41598-021-96419-z
Human study · PubMed trial index
Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.
Elhusseiny R, Ihsan M, Labidi M et al. · Medicine and science in sports and exercise · 2025
PMID 40674654 · DOI: 10.1249/MSS.0000000000003825

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

Review · secondary evidence
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng Y, Wei Z, Wang T et al. · Frontiers in endocrinology · 2023
PMID 36761202 · DOI: 10.3389/fendo.2023.1120533
Research publication · design requires review
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG et al. · Cell metabolism · 2015
PMID 25738459 · DOI: 10.1016/j.cmet.2015.02.009
Research publication · design requires review
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Yin Y, Li Y, Ma B et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
PMID 39321430 · DOI: 10.1002/advs.202405620

MOTS-c supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Compare all MOTS-c sizes, forms and supplier prices →

Supplier	Recorded packages	Example source listing
Blank PeptidesUSD	10mg Vial1 recorded offers	10mg Vial · $55.00Checked Sep 21, 2026Supplier listing
American PeptidesUSD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · $100.00Checked Sep 21, 2026Supplier listing
Modified AminosUSD	10mg Vial · 20mg Vial2 recorded offers	10mg Vial · $34.95Checked Sep 16, 2026Supplier listing
Amino ClubUSD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · $39.99Checked Sep 16, 2026Supplier listing
Nova Peptide SupplyUSD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · $49.99Checked Sep 16, 2026Supplier listing
Amino USAUSD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · $45.00Checked Sep 16, 2026Supplier listing
Cenexa LabsUSD	40mg Vial · 10mg Vial2 recorded offers	40mg Vial · $189.99Checked Sep 16, 2026Supplier listing
US Peptide LabsUSD	20mg Vial1 recorded offers	20mg Vial · $95.00Checked Sep 16, 2026Supplier listing
Direct PeptidesUSD	10mg Vial1 recorded offers	10mg Vial · $49.00Checked Sep 16, 2026Supplier listing
Particle PeptidesEUR	10mg Vial1 recorded offers	10mg Vial · €47.99Checked Sep 16, 2026Supplier listing
PeptiLabCAD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · CA$95.00Checked Sep 17, 2026Supplier listing
Nuvion PeptidesCAD	40mg Vial1 recorded offers	40mg Vial · CA$129.99Checked Sep 21, 2026Supplier listing
AminoVaultUSD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · $59.49Checked Sep 19, 2026Supplier listing
PhaseOneAUD	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · A$63.99Checked Sep 21, 2026Supplier listing
BioStacksCAD	10mg Vial · 20mg Vial2 recorded offers	10mg Vial · CA$90.00Checked Sep 21, 2026Supplier listing
PepspanEUR	10mg Vial1 recorded offers	10mg Vial · €74.90Checked Sep 21, 2026Supplier listing
AllMyPeptidesGBP	10mg Vial · 40mg Vial2 recorded offers	10mg Vial · £24.99Checked Sep 17, 2026Supplier listing

Reference sources & further reading

PubChem compound record 146675088 — chemical identity and structure.
Wikipedia: MOTS-c — Background encyclopedia; not a primary clinical source.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.