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MK-677: molecular data, studies & sources
MK-677 is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.
Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review
Molecular formula, weight & structure
- Molecular formula (MF)
- C27H36N4O5S
- Molecular weight (MW)
- 528.7 g/mol
- PubChem compound ID
- 178024
- Record title
- Ibutamoren
Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.
Source: PubChem CID 178024 · retrieved 2026-09-21
Chemical identifiers and source data
- IUPAC name
- 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
- InChIKey
- UMUPQWIGCOZEOY-JOCHJYFZSA-N
- SMILES
- CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N
Calculated molecular descriptors
| Monoisotopic (exact) mass | 528.2406 Da |
|---|---|
| Heavy atoms | 37 |
| Hydrogen-bond donors | 2 |
| Hydrogen-bond acceptors | 6 |
| Rotatable bonds | 8 |
| Topological polar surface area | 122.0 Ų |
| Calculated logP (Crippen) | 1.77 |
| Rings | 4 |
| Stereocenters | 1 |
| Formal charge | 0 |
Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.
Registered clinical trials
Studies registered on ClinicalTrials.gov that list Ibutamoren as an intervention. Studies that only measure the molecule as a biomarker are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.
4 registered studies matched.
| Study | Phase · status | Conditions | Sponsor · size |
|---|---|---|---|
| A Phase 2, Investigator-Initiated, Randomized, Double-Blind, Placebo-Controlled Study to Determine Growth Hormone Secretagogue MK-0677's Effect on Lean Body Mass in Chronic Kidney Disease Subjects With Stage 4 and Stage 5 Kidney DiseaseNCT01343641 · start 2009-03 · primary completion 2010-04 | Phase 2Withdrawn | Chronic Kidney Disease · Kidney Disease | University of VirginiaEnrollment not listed |
| Growth Hormone Secretagogue MK-0677 Effect on IGF-1 Levels in ESRD PatientsNCT00395291 · start 2006-08 · primary completion 2009-01 | Not applicableCompleted | Chronic Kidney Disease · End Stage Renal Disease | University of Virginia49 participants |
| A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of MK-0677 25 mg in the Treatment of Primary FibromyalgiaNCT00116129 · start 2005-07 · primary completion 2008-01 | Phase 2Completed | Fibromyalgia | Bennett, Robert, M.D.64 participants |
| Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older AdultsNCT00474279 · start 1998-07 | Phase 1 / Phase 2Completed | Aging | University of Virginia72 participants |
Registry check 2026-10-01 · Run this search on ClinicalTrials.gov
Human and clinical studies
Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.
- Human study · PubMed trial index
Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.
Codner E, Cassorla F, Tiulpakov AN et al. · Clinical pharmacology and therapeutics · 2001
PMID 11452249 · DOI: 10.1067/mcp.2001.116514
- Human study · PubMed trial index
MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.
Adunsky A, Chandler J, Heyden N et al. · Archives of gerontology and geriatrics · 2011
PMID 21067829 · DOI: 10.1016/j.archger.2010.10.004
Preclinical research, reviews & other publications
Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.
No additional matching publication was retained. The search links below allow further investigation; they are not evidence that a study exists.
MK-677 supplier sources
Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.
MK-677 for sale: compare prices, sizes and forms from every tracked supplier →
| Supplier | Recorded packages | Example source listing |
|---|---|---|
| Cenexa LabsUSD | 15mg×60 Capsules1 recorded offers | 15mg×60 Capsules · $129.99Checked Oct 7, 2026Supplier listing |
| Amino USAUSD | 25mg-per-mL-30mL Solution1 recorded offers | 25mg-per-mL-30mL Solution · $50.00Checked Oct 7, 2026Supplier listing |
Reference sources & further reading
- PubChem compound record 178024 — chemical identity and structure.
- Wikipedia: Ibutamoren — Background encyclopedia; not a primary clinical source.
The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.
Search for additional research
These links run searches; their results have not been individually reviewed and can include unrelated compounds.
Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.
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