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NAD+: molecular data, studies & sources

A small human pilot study measured plasma and urine metabolites during an intravenous NAD infusion. It examined metabolite handling, not proof of an anti-aging benefit. Trials of NMN, nicotinamide riboside or other precursors are not interchangeable with studies of NAD itself.

Overview sources: PMID 31572171

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C21H27N7O14P2
Molecular weight (MW)
663.4 g/mol
PubChem compound ID
5892
Record title
Nadide

The selected structure is oxidized nicotinamide adenine dinucleotide. NADH and NAD precursors such as NMN or nicotinamide riboside are different chemical identities; their trials are not evidence for direct NAD administration.

Source: PubChem CID 5892 · retrieved 2026-09-21

2D molecular structure for NAD+, PubChem CID 5892
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
InChIKey
BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILES
C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Machine-readable PubChem source
Calculated molecular descriptors
Monoisotopic (exact) mass663.1091 Da
Heavy atoms44
Hydrogen-bond donors7
Hydrogen-bond acceptors17
Rotatable bonds11
Topological polar surface area321.1 Ų
Calculated logP (Crippen)-3.65
Rings5
Stereocenters10
Formal charge0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list NAD+ as an intervention. Studies that only measure the molecule as a biomarker are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

10 registered studies matched, 4 currently active or recruiting.

StudyPhase · statusConditionsSponsor · size
A Randomized, Triple-blind, Placebo Controlled Parallel Clinical Trial to Assess the Absorption, Safety, and Efficacy of an Oral Nicotinamide Adenine Dinucleotide (NAD+) Supplement in Healthy AdultsNCT07692633 · start 2026-08 · primary completion 2027-03Not applicableNot Yet RecruitingNAD+ Bioavailability · NAD+ Safety · NAD+ EfficacyReus Research80 participants
A Pilot Randomized Controlled Study of Combinatorial Gerotherapeutics for Healthspan ImprovementNCT07475546 · start 2025-07-23 · primary completion 2026-04Phase 3Active Not RecruitingHealthspan Improvement · Aging · LongevityAgelessRx30 participants
Safety and Preliminary Efficacy Study of NAD+Supplements (NMN) Combined With Radioimmunotherapy in Advanced Non Small Cell Lung Cancer PatientsNCT06966583 · start 2025-05-01 · primary completion 2027-06-30Phase 1Not Yet RecruitingSolid Tumor · Non Small Cell Lung CancerSichuan University20 participants
Absorption and Tolerability of Injectable Administration of Niagen®+, Nicotinamide Riboside Chloride, a Specialized Form of Vitamin B3, as Compared to NAD+: a Double Blinded, Randomized, Controlled Clinical TrialNCT06919328 · start 2024-10-31 · primary completion 2025-04-30Not applicableRecruitingHealthy AgingNutraceuticals Research Institute70 participants
Effectiveness of Qualia NAD+ Supplementation on Intracellular NAD Levels: A Randomized Double-Blind Parallel TrialNCT06505967 · start 2024-06-10 · primary completion 2024-08-18Not applicableUnknownNAD+ Levels in the BloodQualia Life Sciences200 participants
The Effects of IV Administration of ChromaDex's Niagen®, Nicotinamide Riboside Chloride as Compared to IV Administration of NAD+: A Randomized, Placebo Controlled Clinical TrialNCT06382688 · start 2023-11-13 · primary completion 2024-03-08Not applicableUnknownHealthy AgingNutraceuticals Research Institute53 participants
The Exploratory Study on the Baseline Level of NAD+/NADH in Peripheral Blood Samples of Different Gender and Age Groups of Healthy Adults.NCT05997628 · start 2023-08 · primary completion 2024-05Not applicableUnknownNAD+/NADH in Peripheral Blood MonitoringShanghai Cell Therapy Group Co.,Ltd60 participants
Characterization of the Effects of Oral NAD+ in a Wellness CohortNCT07336836 · start 2022-02-23 · primary completion 2022-06-04Early phase 1CompletedHealth Adult Subjects · Healthy ParticipantsBioNADrx Holdings, Inc. Bryleos60 participants
Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19)NCT04604704 · start 2021-01-28 · primary completion 2023-01-23Phase 2CompletedCovid19 · Long COVID-19 · Post-COVID-19 SyndromeAgelessRx36 participants
The Effects of NAD+-Precursor Supplementation on Energy Metabolism in Physically Compromised ElderlyNCT03310034 · start 2017-11-01 · primary completion 2020-03-06Not applicableTerminatedAging · Mitochondrial FunctionMaastricht University14 participants

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

  1. Human pilot study

    A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD.

    Grant R, Berg J, Mestayer R et al. · Frontiers in aging neuroscience · 2019

    Small human pilot measuring NAD-related metabolites during infusion. It does not demonstrate clinical anti-aging efficacy.

    PMID 31572171 · DOI: 10.3389/fnagi.2019.00257

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

No additional matching publication was retained. The search links below allow further investigation; they are not evidence that a study exists.

    NAD+ supplier sources

    Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

    NAD+ for sale: compare prices, sizes and forms from every tracked supplier →

    SupplierRecorded packagesExample source listing
    Blank PeptidesUSD500mg Vial · 1000mg Vial2 recorded offers500mg Vial · $60.00Stale observation · Checked Sep 30, 2026Supplier listing
    American PeptidesUSD500mg Spray · 1000mg Vial · 500mg Vial3 recorded offers500mg Spray · $100.00Checked Oct 7, 2026Supplier listing
    Amino ClubUSD500mg Vial · 750mg Spray2 recorded offers750mg Spray · $49.99Stale observation · Checked Sep 28, 2026Supplier listing
    Nova Peptide SupplyUSD500mg Vial · 1000mg Spray · 1500mg Spray3 recorded offers500mg Vial · $79.99Checked Oct 6, 2026Supplier listing
    Amino USAUSD1000mg Vial · 500mg Vial2 recorded offers1000mg Vial · $230.00Checked Oct 7, 2026Supplier listing
    Cenexa LabsUSD500mg Vial1 recorded offers500mg Vial · $99.99Checked Oct 7, 2026Supplier listing

    Reference sources & further reading

    The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

    Search for additional research

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    Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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