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Semaglutide: molecular data, studies & sources

Semaglutide is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF)
C187H291N45O59
Molecular weight (MW)
4114 g/mol
PubChem compound ID
56843331
Record title
Semaglutide

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 56843331 · retrieved 2026-09-21

PubChem 2D molecular structure for Semaglutide, CID 56843331
2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.
Chemical identifiers and source data
IUPAC name
18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid
InChIKey
DLSWIYLPEUIQAV-CCUURXOWSA-N
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC6=CN=CN6)N
Machine-readable PubChem source

Human and clinical studies

Selected human-study records are shown with their indexed or reviewed study type. Check the original article for the intervention, formulation and controls; the molecule can also be a comparator or measured variable.

  1. Human study · PubMed trial index

    Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity.

    Garvey WT, Blüher M, Osorto Contreras CK et al. · The New England journal of medicine · 2025

    PMID 40544433 · DOI: 10.1056/NEJMoa2502081

  2. Human study · PubMed trial index

    Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.

    Wilding JPH, Batterham RL, Davies M et al. · Diabetes, obesity & metabolism · 2022

    PMID 35441470 · DOI: 10.1111/dom.14725

  3. Human study · PubMed trial index

    Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

    Marso SP, Bain SC, Consoli A et al. · The New England journal of medicine · 2016

    PMID 27633186 · DOI: 10.1056/NEJMoa1607141

  4. Human study · PubMed trial index

    Once-Weekly Semaglutide in Adults with Overweight or Obesity.

    Wilding JPH, Batterham RL, Calanna S et al. · The New England journal of medicine · 2021

    PMID 33567185 · DOI: 10.1056/NEJMoa2032183

  5. Human study · PubMed trial index

    Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.

    Rubino D, Abrahamsson N, Davies M et al. · JAMA · 2021

    PMID 33755728 · DOI: 10.1001/jama.2021.3224

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

  1. Review · secondary evidence

    Safety of Semaglutide.

    Smits MM, Van Raalte DH · Frontiers in endocrinology · 2021

    PMID 34305810 · DOI: 10.3389/fendo.2021.645563

  2. Review · secondary evidence

    Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis.

    Tan HC, Dampil OA, Marquez MM et al. · Journal of the ASEAN Federation of Endocrine Societies · 2022

    PMID 36578889 · DOI: 10.15605/jafes.037.02.14

  3. Preclinical / laboratory research

    Semaglutide lowers body weight in rodents via distributed neural pathways.

    Gabery S, Salinas CG, Paulsen SJ et al. · JCI insight · 2020

    PMID 32213703 · DOI: 10.1172/jci.insight.133429

Semaglutide supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

Compare all Semaglutide sizes, forms and supplier prices →

SupplierRecorded packagesExample source listing
American PeptidesUSD5mg Vial · 10mg Vial · 20mg Vial3 recorded offers5mg Vial · $60.00Recorded out of stock · Checked Sep 21, 2026Supplier listing
Modified AminosUSD10mg Vial1 recorded offers10mg Vial · $49.99Checked Sep 16, 2026Supplier listing
Blank PeptidesUSD10mg Vial1 recorded offers10mg Vial · $79.00Checked Sep 21, 2026Supplier listing
Amino ClubUSD10mg Vial1 recorded offers10mg Vial · $49.99Checked Sep 16, 2026Supplier listing
Direct PeptidesUSD5mg Vial · 10mg Vial2 recorded offers5mg Vial · $49.00Checked Sep 16, 2026Supplier listing
PeptiLabCAD30mg Vial · 20mg Vial · 10mg Vial3 recorded offers30mg Vial · CA$220.00Checked Sep 17, 2026Supplier listing
Nuvion PeptidesCAD10mg Vial · 30mg Vial2 recorded offers10mg Vial · CA$89.99Checked Sep 21, 2026Supplier listing

Reference sources & further reading

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.

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