SR-9009 (Stenabolic): molecular data, studies & sources

SR-9009 (Stenabolic) is catalogued here as a research compound. This profile brings together the molecular source record, selected indexed publications and available supplier comparisons. Evidence for a named substance does not authenticate a commercial product.

Compiled by PeptideTech Editors · Sources checked 2026-10-09 · Selected bibliography, not a systematic review

Molecular formula, weight & structure

Molecular formula (MF): C20H24ClN3O4S
Molecular weight (MW): 437.9 g/mol
PubChem compound ID: 57394020
Record title: Ethyl 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-1-pyrrolidinecarboxylate

Values describe the selected PubChem molecular entity. Counterions, salt forms, hydration and sequence changes can alter the supplied material. Confirm the exact identity against the supplier specification.

Source: PubChem CID 57394020 · retrieved 2026-10-09

2D molecular structure for SR-9009 (Stenabolic), PubChem CID 57394020 — 2D depiction from PubChem. Open to inspect the full image. This drawing represents the selected record, not a vendor batch test.

Chemical identifiers and source data

IUPAC name: ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate
InChIKey: MMJJNHOIVCGAAP-UHFFFAOYSA-N
SMILES: CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]

Machine-readable PubChem source

Identifiers

PubChem CID: 57394020
CAS Registry Number: 1379686-30-2via ChemIDplus, EPA DSSTox, FDA GSRS
FDA UNII: X5DCA09N30
ChEMBL ID: CHEMBL1961796
InChIKey: MMJJNHOIVCGAAP-UHFFFAOYSA-N
Wikidata: Q15410184

Other names and development codes: SR 9009

CAS numbers are published only from ChemIDplus, EPA DSSTox or the FDA Global Substance Registration System; UNII codes are confirmed in FDA GSRS by structure, sequence or exact name. Checked 2026-10-09.

Calculated molecular descriptors

Monoisotopic (exact) mass	437.1176 Da
Heavy atoms	29
Hydrogen-bond donors	0
Hydrogen-bond acceptors	6
Rotatable bonds	8
Topological polar surface area	75.9 Å²
Calculated logP (Crippen)	4.79
Rings	3
Stereocenters	1
Formal charge	0

Computed with RDKit from the published SMILES (Crippen logP, topological polar surface area). Calculated descriptors are not measured properties of a supplied batch.

Registered clinical trials

Studies registered on ClinicalTrials.gov that list SR-9009 as an intervention. Studies that only measure the molecule as a biomarker, or use it only as a comparator or background arm for another drug, are excluded. A registration describes a planned or completed protocol; it does not report a result. Active studies are listed first.

No registered study naming this compound was matched. This is a documented gap in registry coverage, not proof that no study exists.

Registry check 2026-10-01 · Run this search on ClinicalTrials.gov

Human intervention studies

Selected studies in which participants received SR-9009, with their indexed or reviewed study type. Check the original article for the formulation, population and controls. Studies that only measured the molecule, or used it as a comparator, are listed separately below and are not counted as intervention studies.

No human study that administered this compound was retained in this selected bibliography. This is a documented evidence gap in our selection, not proof that no study exists.

Preclinical research, reviews & other publications

Animal studies, laboratory experiments, reviews and other indexed papers answer different questions. A review is secondary evidence; a case report does not estimate how often an outcome occurs.

Research publication · design requires review
Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence.
Gao LB, Wang YH, Liu ZH et al. · Aging cell · 2021
PMID 34587364 · DOI: 10.1111/acel.13483
Preclinical / laboratory research
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.
Dierickx P, Emmett MJ, Jiang C et al. · Proceedings of the National Academy of Sciences of the United States of America · 2019
PMID 31127047 · DOI: 10.1073/pnas.1904226116
Preclinical / laboratory research
SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis.
Hu M, Zhang L, Cao J et al. · Canadian respiratory journal · 2022
PMID 35814267 · DOI: 10.1155/2022/5802938
Preclinical / laboratory research
A quantitative method for the simultaneous detection of SR9009 and SR9011 in equine plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
Kwak YB, Yu J, Yoo HH et al. · Drug testing and analysis · 2022
PMID 35396832 · DOI: 10.1002/dta.3271
Preclinical / laboratory research
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling.
Huang Q, Tian L, Zhao X et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
PMID 36029539 · DOI: 10.1016/j.biopha.2022.113595
Research publication · design requires review
SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis.
Zheng Z, Cai X, Liu Y et al. · Frontiers in gastroenterology (Lausanne, Switzerland) · 2026
PMID 42564045 · DOI: 10.3389/fgstr.2026.1762028
Preclinical / laboratory research
Limited effects of the REV-ERB agonist SR9009 after mouse spinal cord contusion: Reduced acute pathology with unaffected functional recovery and chronic white matter loss.
Slomnicki LP, Hodges E, Armstrong C et al. · Neuroscience letters · 2025
PMID 41232745 · DOI: 10.1016/j.neulet.2025.138443
Preclinical / laboratory research
LC-HRMS-Based Metabolic Profiling of the REV-ERB Agonist SR9009 in Camel Liver Homogenate and Cunninghamella elegans for Anti-Doping Analysis.
Palathinkal AB, Farook Basha S, Laya S et al. · Rapid communications in mass spectrometry : RCM · 2026
PMID 42530886 · DOI: 10.1002/rcm.70149

SR-9009 (Stenabolic) supplier sources

Scientific sources describe molecules and experiments. The commercial links below identify recorded supplier packages. A publication or chemical database entry does not verify the seller, purity, sterility or contents of a lot. Some links are affiliate links; see our disclosure.

No priced supplier offers are currently available in this catalog view. The research record remains available independently of stock.

Reference sources & further reading

PubChem compound record 57394020 — chemical identity and structure.
FDA Global Substance Registration System: UNII X5DCA09N30 — substance identity, names and codes.

The citations above link directly to publication records. Encyclopedia links are background reading and are not used to establish clinical effectiveness.

Search for additional research

These links run searches; their results have not been individually reviewed and can include unrelated compounds.

Research information is not a dosing guide or a recommendation for personal use. Study findings are specific to the formulation, population and methods tested. Read our source and correction policy.